Sr. Scientist, In Vivo CAR-T

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Sr. Scientist, In Vivo CAR-T as part of the R&D team based in Philadelphia, PA.

Role Overview

Legend Biotechnology is a leader in the development of cutting-edge cell-based therapies. We are seeking a highly motivated and experienced Senior Scientist to join our rapidly expanding in vivo CAR-T cell therapy team. This role offers the opportunity to contribute directly to the advancement of our in vivo CAR-T platform and pipeline.

The ideal candidate will bring deep expertise in cellular immunotherapy and a strong foundation in virology and immunology. You will collaborate across research, development, and manufacturing teams to translate preclinical discoveries into impactful clinical applications. Your scientific insight and collaborative spirit will be essential in driving innovation and improving patient outcomes.

Key technical competencies include lentivirus preparation and execution of ex vivo and in vitro functional assays to assess product potency and safety. The successful candidate will demonstrate scientific rigor, integrity, and the ability to deliver results within timelines, while fostering a culture of teamwork and excellence in a fast-paced environment.

Key Responsibilities

• Lead, design and execute research to develop cell and gene therapy platforms.
• Optimize cell-based immunoassays, including immune cell isolation and expansion, T cell culture, virus packaging and titering, multi-color flow cytometry, ELISA, cell-based cytotoxic assays, PCR analysis.
• Work closely with team to test different designs to deliver reliable and consistent data.
• Document and interpret scientific results, present the data within research team and cross-functional teams.

Requirements

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The anticipated base pay range is

$123,605 - $162,232 USD

Benefits

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity / affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic / civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.