Talent.com
Principal Investigator
Principal InvestigatorMetric • Worcester, MA, US
Principal Investigator

Principal Investigator

Metric • Worcester, MA, US
[job_card.variable_days_ago]
[job_preview.job_type]
  • [job_card.full_time]
[job_card.job_description]

Opportunity : Principal Investigator (General Medicine)

Metric Bio is partnering with a high-performing and rapidly expanding clinical site network based in Massachusetts, in the search for an accomplished Principal Investigator specialising in General Medicine . This is a unique opportunity to lead meaningful clinical research, drive innovation, and directly impact patient outcomes within a cutting-edge US-based organisation.

The Role :

As the Principal Investigator, you will provide expert medical leadership across multiple clinical trials, ensuring scientific integrity, regulatory compliance, and the highest standards of patient safety. You'll be a key contributor in shaping research strategy, guiding clinical teams, and building strong collaborations with sponsors and stakeholders.

Key Responsibilities

  • Serve as the lead Principal Investigator across general medicine clinical trials
  • Oversee all aspects of study conduct, ensuring alignment with protocol, GCP, and FDA standards
  • Conduct medical evaluations, determine eligibility, and monitor patient safety
  • Provide expert input into feasibility assessments and study design
  • Safeguard data quality and ethical integrity across trials
  • Develop and maintain strong sponsor and regulator relationships
  • Mentor and support Sub-Investigators and research teams
  • Champion clinical excellence and continuous process improvement

Required Qualifications & Experience

  • MD / DO with active and unrestricted US medical license.
  • Minimum 5 years' post-licensure experience in general or internal medicine
  • Direct involvement in 10 or more clinical trials (Phase II–IV preferred) as Principal Investigator or Sub-Investigator.
  • Deep understanding of GCP, FDA regulations, ICH guidelines, and clinical governance
  • Proven track record in clinical leadership and decision-making
  • Excellent communication, patient-centric approach, and collaborative mindset

    • What's on Offer

  • Competitive compensation package + comprehensive benefits
  • Opportunity to lead high-impact trials across varied therapeutic areas
  • Innovative, collaborative research environment
  • Professional development & leadership support
  • Make a significant contribution to improving future patient care

    • Interested in Applying?

    If you are an experienced physician with a passion for research leadership and meet the clinical trial experience requirement, we would love to hear from you.

    Contact Metric Bio : oli.oldham@metric-search.com

    [job_alerts.create_a_job]

    Principal Investigator • Worcester, MA, US

    [internal_linking.related_jobs]
    Remote Finance Director - AI Trainer ($50-$60 / hour)

    Remote Finance Director - AI Trainer ($50-$60 / hour)

    Data Annotation • Leominster, Massachusetts
    [filters.remote]
    [job_card.full_time] +1
    We are looking for a finance professional to join our team to train AI models.You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of ...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Infection Prevention Manager

    Infection Prevention Manager

    Saint Vincent Hospital • WORCESTER, Massachusetts, United States
    [job_card.full_time]
    We are a community built on care.Our caregivers and supporting staff extend compassion to those in need, helping to improve the health and well-being of those we serve, and provide comfort and heal...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    PACE Physician - Leominster

    PACE Physician - Leominster

    Fallon Community Health Plan • Leominster, MA, US
    [job_card.full_time]
    Join a Mission-Driven Team at Fallon Health Summit ElderCare!.Worcester, Leominster, Lowell, Springfield, Webster, Dartmouth - come take a tour and meet the team!. Primary Care Physician – PAC...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Fraud Investigator II

    Fraud Investigator II

    InsideHigherEd • Westborough, Massachusetts, United States
    [job_card.full_time]
    Make a Meaningful Impact in Healthcare Integrity.If you're motivated by meaningful work—and enjoy digging into data to uncover trends, patterns, and hidden problems—this role offers both purpose an...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Counselor

    Counselor

    Spectrum Health Systems, Inc • Shirley, MA, United States
    [job_card.part_time]
    Location : MCI Shirley - Shirley, MA.Schedule : Full-time, 40 hours per week.The Counselor ensures that all inmates are provided with education in the assigned curriculum approved by the Department o...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Principal Investigator

    Principal Investigator

    Metric • Worcester, MA, US
    [job_card.full_time]
    Opportunity : Principal Investigator (General Medicine).Metric Bio is partnering with a high-performing and rapidly expanding. This is a unique opportunity to lead meaningful clinical research, drive...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Inpatient Adolescent Psychiatry in Massachusetts

    Inpatient Adolescent Psychiatry in Massachusetts

    Jackson Physician Search • Devens, US
    [job_card.full_time]
    Adolescent Psychiatry in New England Community with Proximity to Boston.For more information, please contact Christen Kolloff : .[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Sr Research Program Manager

    Sr Research Program Manager

    InsideHigherEd • Worcester, Massachusetts, United States
    [job_card.full_time]
    Under the general direction of the Principal Investigator, or designee, the Senior Research Program Manager oversees the application, implementation, progress, and evaluation of complex multi-year,...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Paid Research Panelist (Hiring Immediately)

    Paid Research Panelist (Hiring Immediately)

    Maxion Research • Smithfield, Rhode Island, US
    [job_card.part_time]
    Join Our Part-Time Research Studies Today!.Are you eager to earn extra income from the comfort of your home? We are looking for motivated individuals to participate in paid research studies includi...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Research Analyst I

    Research Analyst I

    US Tech Solutions, Inc. • Worcester, MA, US
    [job_card.full_time]
    Independently generate precise, reliable and reproducible data in a timely manner.Demonstrate experimental precision and strong data interpretation skills and should possess understanding of core d...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Outpatient Forensic Clinician

    Outpatient Forensic Clinician

    Advocates • Marlborough, MA, United States
    [job_card.full_time]
    The Outpatient Forensic Clinician will provide comprehensive outpatient counseling / therapy to children, adults and familiies in need of services. Advocates promotes a healthy work-life balance and o...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Physician (MD / DO) - Psychology in Boston, MA

    Physician (MD / DO) - Psychology in Boston, MA

    LocumJobsOnline • Worcester, Massachusetts, US
    [job_card.full_time] +1
    LocumJobsOnline is working with AAS Locum Tenens to find a qualified Psychology MD in Boston, Massachusetts, 02134!.We are seeking a licensed Psychologist with expertise in Long-Term Acute Care an...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Case Manager - Manager- Remote in MA

    Case Manager - Manager- Remote in MA

    UnitedHealth Group • Worcester, MA, United States
    [filters.remote]
    [job_card.full_time]
    At UnitedHealthcare, we're simplifying the health care experience, creating healthier communities and removing barriers to quality care. The work you do here impacts the lives of millions of people ...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Remote Private Detectives and Investigators - AI Trainer ($80-$120 per hour)

    Remote Private Detectives and Investigators - AI Trainer ($80-$120 per hour)

    Mercor • Leominster, Massachusetts, US
    [filters.remote]
    [job_card.full_time]
    About the Role • • Mercor is seeking experienced • •Private Detectives and Investigators • • to support a leading AI lab in advancing research and infrastructure for next-generation machine learning sys...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Travel Psychologist - School in Woonsocket, RI

    Travel Psychologist - School in Woonsocket, RI

    AlliedTravelCareers • Woonsocket, RI, US
    [job_card.full_time]
    AlliedTravelCareers is working with Aequor to find a qualified Psychologist - School in Woonsocket, Rhode Island, 02895!. With Aequor, you can enjoy the freedom to advance your career and travel the...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Principal Shock and Structural Engineer

    Principal Shock and Structural Engineer

    Leonardo DRS • Fitchburg, MA, United States
    [job_card.full_time]
    The Leonardo DRS Naval Power Systems business is a trusted provider of innovative naval gas and hybrid power systems, control technology and support solutions for the U. Navy and navies around the w...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Travel Nurse RN - Case Manager - $2,390 per week in Melrose, MA

    Travel Nurse RN - Case Manager - $2,390 per week in Melrose, MA

    TravelNurseSource • Worcester, Massachusetts, US
    [job_card.full_time]
    TravelNurseSource is working with GetMed Staffing to find a qualified Case Manager RN in Melrose, Massachusetts, 02176!.GetMed Staffing is searching for a strong Case Manager RN to assist our trave...[show_more]
    [last_updated.last_updated_1_day] • [promoted]
    Clinician

    Clinician

    Spectrum Health Systems, Inc • Shirley, MA, United States
    [job_card.full_time]
    Massachusetts Correctional Institution - Shirley Medium.Health, dental, vision insurance.Discounts on wide array of services / entertainment. Providing documented individual and group clinical service...[show_more]
    [last_updated.last_updated_30] • [promoted]