Principal Process Development Scientist, Downstream BiologicsBlue Signal LLC • San Francisco, CA, United States
Principal Process Development Scientist, Downstream Biologics
Blue Signal LLC • San Francisco, CA, United States
[job_card.variable_days_ago]
[job_preview.job_type]
- [job_card.full_time]
[job_card.job_description]MS / PhD in Chemical Engineering, Biochemistry, Biotechnology, or related discipline with significant industry experience. Deep technical hands-on experience with purification of therapeutic proteins using AKTA or equivalent systems. Proven ability to design and execute experiments, interpret analytical data, and implement process improvements. Experience with scaling processes towards commercial manufacturing and supporting tech transfer. Strong communication skills, with the ability to influence across functions and clearly document scientific decisions. A proactive mindset, able to work independently and collaboratively in a fast-paced development environment. Competitive base salary with bonus eligibility Comprehensive benefits including medical, dental, vision, and retirement Relocation assistance available Opportunities for growth and leadership within a growing organization
Principal Process Development Scientist, Downstream Biologics
Location : San Francisco East Bay (Relocation Support Offered)
Role Overview :
A dynamic, well funded biopharmaceutical organization focused on next generation protein therapeutics is actively building its process development capabilities and is seeking an experienced downstream expert to lead purification science and scaleup efforts. This role is ideal for a hands-on scientist who thrives in a collaborative environment, enjoys solving complex process challenges, and wants ownership of purification strategy from early development through commercial readiness.
What You Will Do :
- Lead design, optimization, and troubleshooting of downstream purification processes for complex protein biologics (including chromatography and filtration strategies).
- Apply experimental design and data driven decision making to refine unit operations and improve process robustness.
- Drive tech transfer of purification processes from bench to pilot and GMP manufacturing, working closely with manufacturing and quality teams.
- Select and implement appropriate chromatography techniques (e.g., ion exchange, hydrophobic interaction, affinity) to meet target purity and yield.
- Oversee tangential flow filtration (TFF), depth filtration, and other downstream unit operations relevant to protein capture and polishing.
- Collaborate with upstream, analytical, and regulatory partners to align on process strategy, documentation, and development timelines.
- Mentor and develop junior scientists and associates as the team grows.
- Contribute to internal process knowledge, standardization, and potentially publications and conference presentations.
What You Bring :
Compensation & Benefits :
About the Opportunity :
This is a strategic hire for a company advancing multiple protein based therapeutics toward later stage clinical development and manufacturing readiness. You will be a core driver of downstream process excellence, shaping purification strategy and execution at a critical phase of growth.
About Blue Signal :
Blue Signal is an award-winning, executive search firm specializing in various specialties. Our recruiters have a proven track record of placing top-tier talent across industry verticals, with deep expertise in numerous professional services. Learn more at bit.ly / 46Gs4yS
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Principal Process Development Scientist Downstream Biologics • San Francisco, CA, United States
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