Bioinformatics Analyst

The Zimmerman lab at OUHSC is broadly focused on understanding the function of monocytes and tissue resident macrophages in mouse models of polycystic kidney disease (PKD), acute kidney injury (AKI), and heart failure with preserved ejection fraction (HFpEF) using state-of-the-art techniques including single cell RNA sequencing (scRNAseq) and spatial transcriptomics. Using omics' approaches, we have defined how disease sequalae alters macrophage phenotype in mouse models and developed monocyte/macrophage specific knockout mice to test the functional importance of predicted cytokines in vivo. We have also set our sights on understanding how omics data from human patients cross-references across model systems including mice, rat, and organoids using deep learning approaches.

Responsible for providing bioinformatics support for research projects, constructing and maintaining databases, and writing programs. Assists researchers by collecting data, keeping records, conducting literature and technical research, analyzing data, preparing reports, and working with other bioinformatics support personnel. Assists with experimental design and interpretation of results.

Duties:

• Analyzes sequencing and proteomic data by importing, examining, and running statistical analyses and modeling algorithms. Analyzes data from a variety of experiments and platforms. Interprets, draws conclusions, and discusses results with principal investigator.
• Develops and maintains relational databases for high throughput data archiving and analysis. Assists with data deposition to public databases.
• Provides user training and assistance to researchers for various bioinformatics software analysis packages and users who wish to incorporate this expertise into their own laboratory.
• Responds to end-user problems and requests relating to genome/proteome data.
• Installs software packages related to bioinformatics.
• Continues to stay abreast of changing technologies, programming language developments, and new product items to support and enhance job performance.
• Performs various duties as needed to successfully fulfill the function of the position.