Talent.com
Bioinformatics Analyst III
Bioinformatics Analyst IIIKatalyst HealthCares & Life Sciences • Cambridge, MA
Bioinformatics Analyst III

Bioinformatics Analyst III

Katalyst HealthCares & Life Sciences • Cambridge, MA
[job_card.30_days_ago]
[job_preview.job_type]
  • [job_card.full_time]
[job_card.job_description]

Job Description :

The successful candidate will work closely with stakeholders across the IPSI (Immune Profiling & Systems Immunology in Immunology Discovery) organization to advance the Single-Cell Fibroblast Atlas initiative. The role will focus on applying AI / ML and advanced computational methods to large-scale single-cell transcriptomic, proteomics and spatial etc. datasets to define fibroblast states, map tissue-specific niches, and uncover their roles in health and disease.

Responsibilities :

  • Curate, harmonize, and analyze large-scale single-cell and spatial omics datasets (internal and public) with emphasis on fibroblast biology.
  • Develop and optimize predictive AI / ML models to classify fibroblast states, identify regulatory networks, and generate disease-relevant insights.
  • Integrate multi-modal data (scRNA-seq, spatial etc.) to construct a comprehensive fibroblast atlas.
  • Collaborate with other stakeholders.
  • By building the Fibroblast Atlas, the candidate will enable target discovery while driving cross-functional projects at the interface of data science, immunology, and translational medicine impacting the portfolio.
  • Support senior analysts and scientists in implementing, training, and troubleshooting AI / ML models tailored to single-cell and spatial omics data.
  • Ingest, clean, and preprocess large-scale single-cell transcriptomic and spatial datasets (public and internal) for single-cell atlas workflows.
  • Collaborate with immunology and computational teams to translate biological questions on fibroblast states, niches, and disease roles into computational solutions.
  • Document data curation, processing, and modeling pipelines to ensure reproducibility and transparency across the atlas project.
  • Assist in interpreting model outputs to generate insights into fibroblast heterogeneity, tissue-specific function.
  • Contribute to time-sensitive projects with critical deliverables, supporting target discovery and prioritization within the fibroblast atlas framework.

Requirements :

  • MS degree (+ years of experience) or PhD (+ years of experience) in a quantitative field (Bioinformatics, Computational Biology, Computer Science, Computational Genetics, Biostatistics, AI / Machine Learning, or related discipline).
  • Proficiency in Python and standard ML / data science libraries.
  • Experience working on HPC or cloud environments for large-scale omics and imaging datasets.
  • Domain knowledge in single-cell analysis, spatial omics, or systems immunology, ideally with exposure to fibroblast or stromal cell biology.
  • Strong attention to detail, documentation, and communication skills.
  • Ability to independently design, execute, and troubleshoot computational workflows.

    • Technical Skills :

  • Experience with NumPy, Pandas, Scikit-learn, Matplotlib, and Seaborn.
  • Familiarity with deep learning frameworks (TensorFlow and / or PyTorch).
  • Proficiency with Git for version control and collaboration.
  • Hands-on experience with single-cell data analysis tools (, Scanpy, Seurat, Bioconductor, or equivalent).
  • Exposure to multi-modal integration methods (, CITE-seq, ATAC-seq, proteomics, imaging mass cytometry, spatial transcriptomics).
  • Experience with OpenCV, Scikit-image, or computer vision models for imaging datasets.
  • Knowledge of cell type annotation, clustering, and trajectory inference methods.
  • Experience building multi-modal AI / ML models that link transcriptomic, proteomic, and imaging data.

    • Top Skills :

  • Implementing, training AI / ML models.
  • Data pre-processing for AI compatibility.
  • Domain knowledge of bioinformatics.
  • Experience working with single cell and spatial data (transcriptomics, proteomics, epigenomics etc.).
  • Ability to communicate results clearly.
    • [job_alerts.create_a_job]

    Analyst Iii • Cambridge, MA

    [internal_linking.related_jobs]
    Applied Researcher II

    Applied Researcher II

    Capital One • Cambridge, MA, US
    [job_card.full_time] +1
    At Capital One, we are creating trustworthy and reliable AI systems, changing banking for good.For years, Capital One has been leading the industry in using machine learning to create real-time, in...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Lead Bioinformatics & Data Infrastructure

    Lead Bioinformatics & Data Infrastructure

    Beth Israel Lahey Health • Boston, MA, United States
    [job_card.full_time]
    A healthcare organization in Massachusetts is seeking a Bioinformatician / Data Infrastructure & Analytics Lead to drive its computational strategy and manage data infrastructure.The ideal candidat...[show_more]
    [last_updated.last_updated_variable_hours] • [promoted] • [new]
    Application Analyst III - healthcare system - primarily Epic - Epic certification preferred

    Application Analyst III - healthcare system - primarily Epic - Epic certification preferred

    Compunnel Inc. • Malden, MA, US
    [job_card.temporary]
    Application Analyst III - healthcare system - primarily Epic - Epic certification preferred.Malden Commerce Place, Malden, MA, 02148. Local candidates within 50 miles preferred.We are seeking a high...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Scientific Business Analyst, Cheminformatics

    Scientific Business Analyst, Cheminformatics

    TetraScience • Cambridge, MA, US
    [job_card.full_time]
    [filters_job_card.quick_apply]
    TetraScience is the Scientific Data and AI company.We are catalyzing the Scientific AI revolution by designing and industrializing AI-native scientific data sets, which we bring to life in a growin...[show_more]
    [last_updated.last_updated_30]
    Bioinformatician II, Pathology

    Bioinformatician II, Pathology

    Mass General Brigham (Enterprise Services) • Somerville, MA, United States
    [job_card.full_time]
    Drives the application of clinical bioinformatics and other clinical / research / education informatics needs in the department through software engineering. Manage multiple bioinformatics coding tasks ...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Bioinformatics Associate — TB Genomics and Phenotype Link

    Bioinformatics Associate — TB Genomics and Phenotype Link

    Harvard University • Boston, MA, United States
    [job_card.full_time]
    A prestigious academic institution in Boston is looking for an Associate in Biomedical Informatics.The role involves conducting bioinformatic analysis and researching correlations in treatment outc...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    2026 Immunology Bioinformatics Intern (PhD)

    2026 Immunology Bioinformatics Intern (PhD)

    AbbVie • Cambridge, Massachusetts, USA
    [job_card.full_time]
    Envision spending your summer working with energetic colleagues and inspirational leaders all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical ind...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Analyst II, Responsible Gaming Analytics

    Analyst II, Responsible Gaming Analytics

    DraftKings • Boston, MA, United States
    [job_card.full_time]
    At DraftKings, AI is becoming an integral part of both our present and future, powering how work gets done today, guiding smarter decisions, and sparking bold ideas. It's transforming how we enhance...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Bioinformaticist I

    Bioinformaticist I

    Harvard University • Boston, MA, United States
    [job_card.temporary]
    By working at Harvard University, you join a vibrant community that advances Harvard's world-changing mission in meaningful ways, inspires innovation and collaboration, and builds skills and expert...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Computational Biology / Bioinformatics / Machine Learning Postdoc - Single Cell and Spatial Technolo

    Computational Biology / Bioinformatics / Machine Learning Postdoc - Single Cell and Spatial Technolo

    Beth Israel Deaconess Medical Center • Boston, MA, US
    [job_card.full_time]
    The Vlachos Lab and the Spatial Technologies Unit (www.AI / ML and computational biology methods.The researcher will have the ability to leverage. Available projects revolve around cancer immunology, ...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Bioinformatician and Data Infrastructure Lead

    Bioinformatician and Data Infrastructure Lead

    Beth Israel Lahey Health • Boston, MA, United States
    [job_card.full_time]
    When you join the growing BILH team, you're not just taking a job, you’re making a difference in people’s lives.The Hide Laboratory at BIDMC and Harvard Medical School applies cutting‑edge genomic ...[show_more]
    [last_updated.last_updated_variable_hours] • [promoted] • [new]
    Senior Expert II AI and Computational Sciences

    Senior Expert II AI and Computational Sciences

    Novartis Group Companies • Cambridge, MA, United States
    [job_card.full_time]
    Novartis has embraced a bold strategy to drive a company-wide digital transformation.Our objective is to position Novartis as an industry leader by proactively adopting digital technologies that fo...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Biologist II

    Biologist II

    US Tech Solutions, Inc. • Cambridge Massachusetts, MA, US
    [job_card.temporary]
    Duration : 06 months contract Job Description : We are currently seeking a highly motivated and passionate scientist to join our team in Immunology Discovery department based in Cambridge MA.The cand...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Sales Operations Analyst II

    Sales Operations Analyst II

    OpenGov • Boston, MA, United States
    [job_card.full_time]
    OpenGov is the leader in AI and ERP solutions for local and state governments in the U.More than 2,000 cities, counties, state agencies, school districts, and special districts rely on the OpenGov ...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    CoOp, Computational Biology

    CoOp, Computational Biology

    Ginkgo Bioworks • Boston, MA, United States
    [job_card.full_time]
    Our mission is to make biology easier to engineer.Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe's growing challenges in health, energy, food, materi...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Senior Associate Scientist, Bioinformatics

    Senior Associate Scientist, Bioinformatics

    Alnylam Pharmaceuticals • Cambridge, MA, United States
    [job_card.full_time]
    With six commercially approved RNAi therapeutics, Alnylam is at the forefront of gene silencing.Our success is built upon a rational, sequence-based approach to drug design driven by predictive mod...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Senior Epic Analyst (Beacon)

    Senior Epic Analyst (Beacon)

    Children's Hospital Boston • Boston, MA, United States
    [job_card.full_time]
    BRJob Posting Title : Senior Epic Analyst (Beacon)Department : Information Services-Clinical ApplicationsAutoReqId : 82280BRStatus : Full-TimeStandard Hours per Week : 40 Job Posting Category : Information Tec...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Business Analyst III

    Business Analyst III

    eTeam Inc • Cambridge, Massachusetts, United States
    [job_card.full_time]
    [filters_job_card.quick_apply]
    We are one of the most exciting pipelines in the Biotech / Pharmaceutical industry.Along with this growth comes a number of exciting opportunities to work with our expanding business areas.Within R...[show_more]
    [last_updated.last_updated_30]