Talent.com
Senior Clinical Data Manager (RWE/RWD) # 4426
Senior Clinical Data Manager (RWE/RWD) # 4426GRAIL Inc • Menlo Park, California, United States
[error_messages.no_longer_accepting]
Senior Clinical Data Manager (RWE/RWD) # 4426

Senior Clinical Data Manager (RWE/RWD) # 4426

GRAIL Inc • Menlo Park, California, United States
[job_card.30_days_ago]
[job_preview.job_type]
  • [job_card.full_time]
[job_card.job_description]
Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Senior Clinical Data Manager (CDM) will lead data management activities for one or multiple diagnostic product development studies in support of GRAIL’s robust clinical development pipeline.

This role is based in Menlo Park, California, and will move to Sunnyvale, California in Fall 2026. It offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 40%, or 16 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 40% requirement for the site. At our Menlo Park campus, Tuesdays and Thursdays are the key days where we encourage on-site presence to engage in events and on-site activities.
Responsibilities:
  • Work closely with GRAIL study team members to ensure that clinical and real-world data captured is complete, consistent, and accurate across all data sources.
  • Perform study startup activities such as study protocol review, Clinical Data Management Plan (CDMP) development, and Electronic Data Capture (EDC) set-up, while collaborating with Clinical Technology staff to integrate EDC with external and real-world data sources (e.g., EHR, laboratory, registry, or other vendor-provided datasets).
  • Manage study conduct activities including facilitation of study team data review, documentation of data handling decisions, issuance of data queries, and resolution of data discrepancies across traditional clinical and real-world data sources.
  • Utilize programming skills to create listings and dashboards as required by study team members, including review and reconciliation of external or real-world datasets.
  • Lead data locking efforts, ensuring that study team members have executed according to the CDMP and that all contributing data sources are appropriately reviewed and documented.
  • Ensure that data integrity is maintained throughout the data lifecycle for sources including clinical data, external bio-specimen storage data, real-world data (RWD), and data produced by ultra-deep ctDNA sequencing laboratories.
  • Ensure that documentation is maintained in a state of constant audit-readiness and filed in the Trial Master File.
  • Create and/or review Data Transfer Plans (DTPs) with external data providers or collaborators, including vendors supplying real-world or observational data.
  • Assist the Director of Clinical Data Management and other GRAIL staff with developing and implementing data standards, controlled procedural documents, and software development efforts supporting both interventional and real-world data collection models.


Required Qualifications:
  • Bachelor's degree with 5+ years of industry experience in clinical data management within the pharmaceutical, biotechnology, diagnostics, or healthcare industry in an FDA-regulated environment, including experience supporting studies that incorporate real-world data (RWD) or real-world evidence (RWE) required.
  • Experience working on IDE trials and device registries within the medical device and/or pharmaceutical industry.
  • Prior experience leading mid to large scale clinical trials and ability to support multiple projects at a given time.
  • Understanding of Real World Data (RWD) and Real World Evidence (RWE).
  • Knowledge of regulatory requirements (e.g. ICH, GCP, HIPAA).
  • Strong interpersonal communication (written and verbal) and organizational skills.
  • Excellent team player with demonstrated track record of success in a cross-functional team environment.
  • Consistent commitment to delivering on team goals with a sense of shared urgency.
  • Experience managing vendors and partnering with collaborators to deliver according to contracts and plans.
  • Familiarity with various data visualization, analytics, and reporting tools (e.g. tableau).
  • Prior experience working on the sponsor side is required
  • Experience working on developing/reviewing standard operating procedures for clinical data management in collaboration with cross functional teams required.



Preferred Qualifications:
  • Advanced degree (with epidemiology, informatics) preferred.
  • Solid understanding of programming, analytics, or related disciplines is strongly desired.
  • Experience working with EDC systems, with some EDC build experience is preferred.
  • Experience programming in R, SAS, Python is preferred.
  • Molecular diagnostics industry experience preferred.


Physical Demands and Work Environment:
  • Hours and days may vary depending on operational needs.
  • Standing or sitting for long periods of time may be necessary.
  • Some lifting (up to 25 pounds) may be necessary
  • Requires that a minimum of 40%, or 24 hours, of your total work week be on-site.


The expected, full-time, annual base pay scale for this position is $109K - $144K for Menlo Park, CA. Actual base pay will consider skills, experience, and location.

This role may be eligible for other forms of compensation, including an annual bonus and/or incentives, subject to the terms of the applicable plans and Company discretion. This range reflects a good-faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package, offered in accordance with our applicable plans and policies. This package currently includes flexible time-off or vacation; a 401(k) retirement plan with employer match; medical, dental, and vision coverage; and carefully selected mindfulness programs.

GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, , or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at [email protected] if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!
[job_alerts.create_a_job]

Senior Clinical Data Manager (RWE/RWD) # 4426 • Menlo Park, California, United States

[internal_linking.similar_jobs]

Senior Clinical Trial Manager

SciProSan Francisco, CA, United States
[job_card.full_time]

Working alongside an exciting biotechnology company that focuses on the development and commercialization of therapies for oncology diseases.We are looking for an experienced and driven Clinical Tr...[internal_linking.show_more]

 • [job_card.promoted]

Clinical Manager, Home Health

Sutter HealthAlameda, CA, United States
[job_card.full_time]

We are so glad you are interested in joining Sutter Health! Organization: SCAH-Sutter Care at Home - Bay Position Overview: $5,000 sign-on bonus available to external candidates - in accordance wit...[internal_linking.show_more]

 • [job_card.promoted]

Clinical Data Management Director

Exelixis Inc.Alameda, CA, United States
[job_card.full_time]

SUMMARY/JOB PURPOSE: The Clinical Data Management (CDM) Director is a highly experienced and influential leader with expert knowledge of Clinical Data Management concepts and processes.This positio...[internal_linking.show_more]

 • [job_card.promoted]

Director, Clinical Data Management

The Lotus Group LLCSan Mateo, CA, United States
[job_card.full_time]

Global Pharmaceutical Company | Hybrid — Weekly On-Site Required.A global pharmaceutical company is looking for a Director of Clinical Data Management to lead data operations across a growing clini...[internal_linking.show_more]

 • [job_card.promoted]

Clinical Research Manager - Heme Malignancy Program

University of California - San FranciscoSan Francisco, California, United States
[job_card.full_time]

Job Summary :We are looking to hire a.The Heme Malignancy research program is a fast-paced environment and the successful candidate will be an independent, detail-oriented individual with drive and...[internal_linking.show_more]

 • [job_card.promoted]

Clinical Manager (BCBA)

CatalightBurlingame, CA, United States
[job_card.full_time]

Who We Are: For nearly 10 decades, Easterseals Northern California has provided services to people with disabilities and their families, helping them live, learn, work and play to their full potent...[internal_linking.show_more]

 • [job_card.promoted]

Clinical Manager

Tenderloin Neighborhood Development CorporationSan Francisco, CA, United States
[job_card.full_time]

TITLE: Clinical Manager REPORTS TO: Director of Social Work and Community Services DEPARTMENT: Tenant and Community Services STATUS: Regular, full-time FLSA STATUS: Exempt WAGE RANGE: $109,000 - $1...[internal_linking.show_more]

 • [job_card.promoted]

Senior Manager, Clinical Data Management

Mirum Pharmaceuticals IncSan Mateo, CA, United States
[job_card.full_time]

MISSION Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases.We are passionate about advancing scientific discoveries to become important me...[internal_linking.show_more]

 • [job_card.promoted]

Senior Clinical Data Scientist: Home Health Data & Impact

Sprinter HealthSan Francisco, CA, United States
[job_card.full_time]

A healthcare technology firm in San Francisco is hiring a Senior/Staff Data Scientist to transform messy real-world healthcare data into actionable insights.This hybrid role involves tackling high-...[internal_linking.show_more]

 • [job_card.promoted]

Senior Clinical Research Associate

Enigma SearchSouth San Francisco, CA, United States
[job_card.full_time]

Our client is a clinical-stage biotechnology company focused on building the.At the core of their work is homology directed repair (HDR), a.By leveraging natural repair processes evolved over time,...[internal_linking.show_more]

 • [job_card.promoted]

Senior Manager, Statistical Programming (Oncology)

AbbVie, IncSan Francisco, CA, United States
[job_card.full_time]

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.We strive to...[internal_linking.show_more]

 • [job_card.promoted]

Senior Clinical Trial Manager

GQRAlameda, CA, United States
[job_card.full_time]

Senior Clinical Trial Assistant (Sr.CTA) - Clinical Development Operations.San Francisco / South San Francisco, CA (Hybrid - 3 days onsite/week; remote considered).Our client is a clinical-stage bi...[internal_linking.show_more]

 • [job_card.promoted]

Clinical & Financial Performance Manager

AccentureSan Francisco, CA, United States
[job_card.full_time]

Job Description Accenture is a global leader in professional services, helping organizations worldwide transform their operations, enhance their growth, and deliver sustainable outcomes across indu...[internal_linking.show_more]

 • [job_card.promoted]

Senior Manager, Clinical Business Systems

Revolution Medicines, Inc.Redwood City, CA, United States
[job_card.full_time]

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers.The company's R&D pipeline comprises RAS(ON) inhibitors des...[internal_linking.show_more]

 • [job_card.promoted]

Manager, Clinical Science, Medical Affairs

DanaherSan Francisco, CA, United States
[job_card.full_time]

Are you ready to accelerate your potential and make a real difference within life sciences, diagnostics and biotechnology? At Integrated DNA Technologies (IDT), one of Danaher's 15+ operating compa...[internal_linking.show_more]

 • [job_card.promoted] • [job_card.new]

Clinical Manager

PromaxoOakland, CA, United States
[job_card.full_time]

We are seeking a dynamic and experienced Clinical Manager to join our innovative, fast-growing MRI company, Promaxo.As Clinical Manager, you will play a pivotal role in shaping and executing our cl...[internal_linking.show_more]

 • [job_card.promoted]

Clinical Management Manager

AccentureSan Francisco, CA, United States
[job_card.full_time]

Job Description Accenture is a global leader in professional services, helping organizations worldwide transform their operations, enhance their growth, and deliver sustainable outcomes across indu...[internal_linking.show_more]

 • [job_card.promoted]

Senior Manager, Data Science - Patient Growth

HeadwaySan Francisco, CA, United States
[job_card.full_time]

Headway's mission is a big one - to build a new mental health care system everyone can access.We've built technology that helps people find great therapists with the first software-enabled national...[internal_linking.show_more]