Specialist in Structural Biology •

Application Window

Open date : October 23, 2025

Most recent review date : Friday, Nov 7, 2025 at 11 : 59pm (Pacific Time)

Applications received after this date will be reviewed by the search committee if the position has not yet been filled.

Final date : Friday, Apr 23, 2027 at 11 : 59pm (Pacific Time)

Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

Specialist in Structural Biology

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking an outstanding and motivated individual to join our cutting- edge research institute aimed at discovering new therapies for neurodegenerative diseases. The successful incumbent will work as a structural biology specialist focused on deciphering the structural basis for neurodegenerative diseases, including Alzheimer's disease (AD), frontotemporal dementia (FTD), multiple system atrophy (MSA) and Parkinson's disease (PD). This will involve solving high-resolution cryo-EM and / or cryo-ET structures of disease-relevant filaments, including co-structures with therapeutic targets.

The IND cryo-EM facility is state of the art and includes a Titan Krios G4, Glacios, and L120C TEM instruments, as well as a Helios Hydra plasma FIB-SEM. The IND is directed by Nobel Laureate Dr. Stanley Prusiner and located at the Sandler Neurosciences Center at UCSF's Mission Bay campus, a world-renowned hub of biomedical research and discovery.

The successful applicant will be an expert structural biology researcher with experience in the determination of atomic-resolution structures of protein macromolecules. They will be responsible for applying these methods and skills to support drug discovery and other research efforts at the IND. The incumbent will be a skilled communicator and collaborate with team members across disciplines at the IND and UCSF to advance cryo-EM research efforts to understand the structural basis of neurodegenerative disease-relevant protein macromolecules.

Personal Qualifications

Required :

• Possess a high sense of responsibility for his or her own career development, as well as for the wellbeing of our organization.
• Willingness to receive training and guidance from senior investigators as well as serve as a mentor to trainees on the project.

Education and Training Qualifications :

Required :

Full Specialist - terminal degree (or equivalent degree) in Chemistry, Biophysics, or related field or ten or more years of experience in the relevant specialization

Technical Qualifications

Required :

Preferred :

Candidates must meet the required qualifications at the time of appointment. Application materials must state qualifications (or if pending) upon submission.

This is a full-time position with excellent benefits. Salary is dependent upon experience.

Please apply online at https : / / aprecruit.ucsf.edu / JPF05834 , with a CV, cover letter, and 3 references.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $55,000-$194,800.

Application Requirements

Document requirements

Curriculum Vitae - CV must clearly list current and / or pending qualifications (e.g. board eligibility / certification, medical licensure, etc.).

Cover Letter

Reference requirements

About UC San Francisco

As a University employee, you will be required to comply with all applicable University policies and / or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.

Job location

San Francisco, CA