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Postdoctoral Fellow Position in DNA Damage Response, Radiation Biology, and Immunotherapy
Postdoctoral Fellow Position in DNA Damage Response, Radiation Biology, and ImmunotherapyMayo Clinic • Rochester, MN, United States
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Postdoctoral Fellow Position in DNA Damage Response, Radiation Biology, and Immunotherapy

Postdoctoral Fellow Position in DNA Damage Response, Radiation Biology, and Immunotherapy

Mayo Clinic • Rochester, MN, United States
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Mayo Clinic Cancer Center – Callaghan / Mutter / Lou Laboratory

The Callaghan / Mutter / Lou Laboratory at world-renowned Mayo Clinic Cancer Center and Novel Therapeutics and Therapeutic Modalities Program is seeking a highly motivated Postdoctoral Fellow to join our dynamic team. Our research focuses on DNA Damage Response and Radiation Biology for cancer therapy, particularly their interplay with anti-tumor immunity. This opportunity is centered on advancing treatments for rectal cancer using particle beam radiotherapy, DNA repair inhibitors, and immunotherapy.

Who We Are

Our lab is a highly collaborative and innovative research environment led by experts in the field :

  • Dr. Zhenkun Lou  – A world leader in DNA damage biology, with multiple NIH-funded grants and high-impact publications.
  • Dr. Cameron Callaghan & Dr. Robert Mutter  – Physician-scientists specializing in Radiation Oncology, with expertise in translational clinical trials and pre-clinical mechanistic research.

We work alongside top cancer biologists, clinicians, and global investigators to push the boundaries of radiation and DNA damage / repair mechanisms in cancer therapy. Some of the key questions we explore include :

  • How can rectal cancer be sensitized to radiotherapy while minimizing normal tissue toxicity?
  • What are the unique DNA damage responses induced by high-LET radiation (e.g., Bragg Peak protons, alpha particles, carbon ions)?
  • How can high-LET radiation and DNA repair inhibitors enhance the response of proficient Mismatch Repair (pMMR) rectal cancer to immunotherapy?

    • Your Role

    As a Postdoctoral Fellow, you will spearhead cutting-edge projects focusing on novel radiation techniques, small molecule radiosensitizers, and immunotherapy for rectal cancer. Your research will involve :

  • State-of-the-art experimental techniques, including BP proton irradiation in murine tumor models, in vitro alpha particle irradiation, and advanced molecular biology methods.
  • Multi-omics and imaging approaches, such as multiplexed immunofluorescence, flow cytometry, RNA-seq, whole-exome sequencing (WES), and spatialomics in tumor models and patient-derived tissues.
  • Investigating how high-LET radiation uniquely damages cancer cells, leading to cancer-specific radiosensitization and enhanced immunotherapy responses.

    • Why Join Us?

    Joining the Callaghan / Mutter / Lou Lab means becoming part of an environment that nurtures scientific growth and career development. We offer :

  • Access to world-class resources, mentorship, and training
  • Opportunities to present at major conferences and collaborate globally
  • A supportive environment where you can mentor and be mentored, shaping the future of cancer research

    • Lab Culture

    We thrive on teamwork, diversity, and innovation. Expect a collaborative and inclusive atmosphere, with regular lab meetings, social events, and a shared commitment to advancing cancer research.

    Our Recent Work

    Explore some of our latest publications :

    If you’re ready to make a significant impact in  radiation oncology and cancer biology , we encourage you to apply. You may also contact Dr. Cameron Callaghan directly at

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    Postdoctoral Fellow • Rochester, MN, United States

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