Scientist- SBX Molecular Engineering

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The Position

SCIENTIST (Oligo Synthesis) - SBX MOLECULAR ENGINEERING

A healthier future. Its what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. Thats what makes us Roche.

We advance science so that we all have more time with the people we love.

Roche Diagnostics acquired Stratos Genomics ( in 2020 for its unique chemistry that advances DNA sequencing by nanopore Sequencing by Expansion (SBX). You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate the Xpandomer which significantly improves the accuracy and throughput of nanopore sequencing.

The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes. We are looking for people who are excited about the significance of our technology and want to make SBX successful.

• Please include a cover letter outlining why you want to work with us your specific interest in SBX technology (technical) and how you would contribute this is important.

The Opportunity :

Research design and execute innovative and well-controlled experiments with high attention to detail.

Identify and troubleshoot problems in creative ways.

Contribute to the definition and timely achievement of project goals.

Follow SOPs to aid in the production of reagents and starting materials

Participate in the production of reagents and starting materials.

Perform data analysis and protocol development.

Maintain accurate detailed and reliable laboratory records.

Present findings at group or departmental meetings.

Maintain the labs cleanliness and organization.

Develop and propose improved processes to fulfill the above functions.

Who You Are :

You have a minimum of 2 years laboratory experience in advanced oligo synthesis (e.g. use and development of non-standard phosphoramidites and reagents branched or cyclic structures and instrument modification)

You hold a Bachelors degree in Organic Synthesis Chemistry Chemical Engineering Biochemistry or related field; or equivalent combination of education and work experience MS or PHD Preferred. 5 years of experience less with advanced degrees.

Ideally you will have :

Demonstrated ability to understand and develop novel chemistry for automated oligo synthesis :

Coupling of Phosphoramidites

Oxidation

Detritylation

Capping

Able to manipulate and engineer novel solutions with complex automated fluidics (i.e. Automated Oligo Synthesizers)

Mature understanding of how to work with chemical and biochemical samples including sample handling reactivity purification and storage.

Technical background in next-generation DNA sequencing

Experience with HPLC MS NMR inert atmosphere chambers and manual pipetting.

Relocation benefits are available for this posting .

The expected salary range for this position based on the primary location of Seattle WA is 80500.00 - 149500.00 Annual . Actual pay will be determined based on experience qualifications geographic location and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed here :

Benefits

Who we are

A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.

Lets build a healthier future together.

Roche is an equal opportunity employer. It is our policy and practice to employ promote and otherwise treat any and all employees and applicants on the basis of merit qualifications and competence. The companys policy prohibits unlawful discrimination including but not limited to discrimination on the basis of Protected Veteran status individuals with disabilities status and consistent with all federal state or local laws.

If you have a disability and need an accommodation in relation to the online application process please contact us by completing this form Accommodations for Applicants.

Key Skills

Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills

Employment Type : Full-Time

Experience : years

Vacancy : 1