Science Team Lead - Epigenetic Reprogramming

Job Description

Job Description

About us

e184 is a biotechnology research company advancing in vitro gametogenesis to transform reproductive medicine. We're developing integrated platforms that combine cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges. We're assembling interdisciplinary teams across cell and molecular engineering, synthetic biology, epigenetic editing, bioinformatics and computational biology to tackle one of biology's most impactful problems - returning the fundamental right to procreate.

Role overview

We are seeking a Science Team Lead to drive our innovative research program developing advanced epigenetic editing technologies for therapeutic applications. This is a leadership position reporting directly to the Chief Scientific Officer (CSO) . The successful candidate will guide scientific planning, supervise project execution, contribute to team building, and shape the long-term R&D roadmap.This is a hands-on role : in addition to team leadership and project management, the candidate will be directly involved in designing and conducting experiments , especially in early stages of the program.

What you will do

• Lead a focused research team of 4-6 scientists and report directly to the CSODesign and personally conduct experiments in DNA methylation editor optimization and validation
• Develop guide RNA libraries targeting chromatin regulatory regions
• Establish protocols for targeted methylation editing with persistence validation through cell divisions
• Create delivery strategies for enhanced efficiency in challenging cell types
• Execute single and multiplex editing approaches with maintained specificity across targets
• Drive progression from cell culture proof-of-concept to functional validation in mammalian models
• Define research approaches and priorities aligned with company objectives
• Drive scientific output, IP development, and milestone achievement within established timelines

Required qualifications

Preferred qualifications

What we offer

Disclaimer

The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of e184.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.