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Analytical Scientist - Anti Body Drug Conjugates
Analytical Scientist - Anti Body Drug ConjugatesVeranova L P • Devens, MA, US
Analytical Scientist - Anti Body Drug Conjugates

Analytical Scientist - Anti Body Drug Conjugates

Veranova L P • Devens, MA, US
[job_card.30_days_ago]
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  • [job_card.full_time]
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Job Description

Job Description

Discover Veranova :

At Veranova, we believe people are our most important asset, and we are dedicated to building the most talented workforce in our industry. Our commitment to uncompromising focus on quality, compliance, safety, and excellence in delivery shapes everything we do. We are not just looking for skills; we are seeking innovative individuals who have a mindset open to learning and growth, and a desire to make a difference.

Veranova is a global leader in the development and manufacturing of complex active pharmaceutical ingredients (APIs) for pharma and biotech customers. With deep technical expertise and impressive flexibility, we develop solutions and processes that support and accelerate innovation.

Join us on our mission to enable current and next-generation therapeutics to improve and save the lives of patients.

Role Overview :

We are seeking a highly motivated and skilled Analytical Scientist to join our Analytical team in New England. The successful candidate will have expertise in LCMS (Liquid Chromatography-Mass Spectrometry) based characterization of complex bioconjugates, with a strong understanding of ADC structure and stability.

Core Responsibilities :

  • Exercise technical judgment in the planning, implementation, and analysis of experiments related to method development, validation, reference standard creation and qualification, forced degradation, product characterization, and compatibility studies in accordance with pertinent ICH regulatory guidelines.
  • Develop and optimize LCMS methods for qualitative and quantitative analysis of ADCs. Develop and validate quantitative LCMS methods such as :

Drug-to-Antibody Ratio (DAR) determination.

  • Payload quantification (free and conjugated forms).
  • Linker stability and degradation profiling.
  • Site-specific conjugation analysis.
  • Perform intact mass analysis, peptide mapping, drug-to-antibody ratio (DAR) determination, and payload identification.
  • Characterize ADCs for critical quality attributes including conjugation sites, linker stability, and degradation products.
  • Author test methods, protocols, reports, and regulatory documents as needed.
  • Provide support for development and cGMP manufacturing campaigns, ensuring compliance with regulatory requirements and documentation standards - including both in-process and release samples.
  • Adhere to safety and quality standards.
  • Communicate technical findings and results to both internal and external stakeholders, including clients and regulatory bodies.
  • Collaborate with chemistry development scientists, quality control and regulatory affairs teams to ensure successful project delivery.
  • Mentor and develop scientific staff. Ensure continued technical and professional growth of department members, encourage efforts towards excellence and knowledge sharing.
  • Possess strong communication (oral, written), organizational, and leadership skills.
  • Maintain and troubleshoot LCMS instrumentation (e.g., Orbitrap, Q-TOF, Triple Quad).

    • Qualifications : Required

  • Ph.D., M.S., or B.S. in Analytical Chemistry, Biochemistry, Chemistry, Chemical / Biomedical Engineering, or other related scientific discipline.
  • Relevant experience in analytical method development, validation and characterization of bioconjugates. (PhD with 4+ years, MS with 6+ years, BS with 8 + years of experience.
  • 4+ years of hands-on experience in LCMS analysis of biologics, preferably ADCs.
  • Strong knowledge of protein chemistry, conjugation technologies, and biotherapeutic development.
  • Proficiency in any of the software tools for MS data analysis (e.g., Xcalibur, MassHunter, Skyline, Biopharma Finder).
  • Well organized with good problem-solving skills, a high level of attention to detail and have a passion for delivering high quality data in a fast-paced environment.

    • Preferred

  • Experience with regulatory submissions and GMP / GLP environments.
  • Experience with various techniques used in the characterization of ADC’s such as capillary electrophoresis (CE-SDS) for ADC purity and size analysis, hydrophobic interaction chromatography (HIC) for DAR profiling, size-exclusion chromatography (SEC) for aggregation and stability studies, UV-Vis spectroscopy and fluorescence-based assays for payload quantification, and immunoassays (ELISA, ECL) for antibody detection.

    • Salary Range : $100,000 - $120,000 annual base salary

    Our Commitment :

  • Health & Wellness : Comprehensive health & wellness benefits. Access to mental health resources and wellness programs. Generous PTO and holiday pay policies.
  • Financial Wellness : Veranova is committed to fair and transparent compensation practices. This includes a competitive base salary, eligibility for performance-based bonuses, and an attractive 401(k) Plan with company match. Salary ranges reflect the scope and expectations of the role, and are based on market data, internal equity, and role-specific factors. Final compensation may vary depending on experience, skills, education, and business needs.
  • Professional Development : Opportunities for continuous learning through LinkedIn Learning, workshops, conferences, and mentorship. Tuition Assistance for Undergraduate and Graduate degree programs.
  • Inclusive Culture : At Veranova, an inclusive culture is integral to our values. We welcome people with diverse experiences and perspectives who share our mission to improve and save lives. Even if you don’t meet every qualification, we encourage you to apply. Veterans, first responders, and those transitioning from military to civilian life bring valuable skills that strengthen our team

    • Additional Information :

    Applicants for this role must be authorized to work in the United States without further employer sponsorship.

    Agency and Search Firm Representatives : Veranova does not accept unsolicited resumes from agencies and / or search firms for this job posting.

    All your information will be kept confidential according to EEO guidelines.

    Veranova is an Equal Opportunity Employer. It is the policy of Veranova to provide equal employment access and opportunity to all persons regardless of age, race, color, national origin, religion, sex, sexual orientation, gender identity and / or expression, physical or mental disability, genetic information, citizenship, marital status, veteran status, or any other characteristic protected by federal, state, or local law.

    All applications are carefully considered, and your details will be stored on our secure Application Management System. This is used throughout Veranova for the selection of suitable candidates for our vacancies as they arise. Veranova respects your privacy and is committed to protecting your personal information. For more information about how your personal data is used please view our privacy notice.

    #LI-Onsite

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