Sr. Biostatistician

Job Description:

We are seeking a highly motivated and qualified leader to join our Biostatistics Department as a Senior Biostatistician and work as a team lead to drive success. The Senior Biostatistician will provide strategic and hands-on statistical leadership to support the discovery, development, and clinical advancement of RNA-based therapeutics. This role partners closely with cross-functional teams to design, analyze, and interpret complex data across preclinical and clinical programs, ensuring scientific rigor and regulatory compliance throughout the drug development lifecycle.

Key Responsibilities

• Lead statistical strategy, study design, and data analysis for RNA-based programs across discovery, preclinical, and/or clinical development.
• Develop statistical analysis plans (SAPs), protocols, and supporting documentation in alignment with regulatory expectations.
• Provide statistical expertise for dose-finding, PK/PD modeling, biomarker analysis, and translational studies.
• Collaborate cross-functionally with Clinical Development, Biometrics, Bioinformatics, Regulatory, and Discovery teams.
• Oversee and review statistical outputs from CROs and external partners, ensuring quality and adherence to timelines.
• Perform and interpret advanced statistical analyses using appropriate methodologies for high-dimensional and longitudinal data.
• Contribute to regulatory submissions, investigator brochures, clinical study reports, and scientific publications.
• Communicate statistical results clearly to both technical and non-technical stakeholders.
• Mentor junior statisticians and contribute to best practices within the biostatistics function.

Essential Physical Characteristics:

Reasonable accommodation(s) may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis.

On-Site Protocol:

Physical presence at the ADARx Pharmaceuticals worksite is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture. Remote work is on a case-by-case basis.

Qualifications

• PhD or MS in Biostatistics, Statistics, Mathematics, or a related quantitative field.
• 5+ years of biostatistics experience in the pharmaceutical or biotechnology industry.
• Direct experience supporting RNA-based therapeutics (e.g., siRNA, mRNA, antisense oligonucleotides).
• Strong understanding of drug development processes, including preclinical and clinical trial design.
• Proficiency in statistical programming and analysis tools (e.g., SAS, R).
• Experience working with CROs and managing outsourced statistical activities.
• Knowledge of regulatory guidelines (ICH, FDA, EMA) and submission requirements.
• Excellent written/verbal communication, collaboration, and problem-solving skills are essential for this role.

Preferred Qualifications

• Experience with early-phase clinical trials and translational medicine.
• Familiarity with bioinformatics or omics-related data analysis.
• Prior involvement in regulatory interactions or submissions.
• Demonstrated leadership or mentoring experience.

Required Key Attributes:

• Must be able to work independently with supervision as needed.
• Must be collaborative, work well with other team members in a matrix team environment.
• Strong organizational skills with attention to detail and accuracy.
• Ability to maintain a high level of confidentiality and exercise discretion.
• Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges.
• Understand project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.

Compensation:

• This is a full-time position, Monday-Friday.
• Pay is commensurate with experience.
• Equity-based compensation
• Performance-based bonuses
• 401(k) with Company Match
• Medical, Dental, Vision
• Flexible Spending Account
• Life Insurance
• Employee Assistance Program
• Employee Discounts
• Gym Membership
• Paid Vacation
• Paid Holidays
• Paid Sick, Jury Duty, Bereavement

Work Authorization:

• United States (Required)
• Background Check
• As a condition of employment, you must successfully complete all post-offer, pre-employment requirements, including but not limited to a background check.

Company Overview:

ADARx Pharmaceuticals, Inc., (the “Company” or “ADARx”) located in San Diego, is a late-clinical stage biotechnology company committed to turning cutting-edge science into life-saving therapeutics. ADARx has developed proprietary RNA targeting platforms and technology for silencing or editing target mRNA. ADARx has a growing pipeline of RNA targeting therapeutics for treating diseases across a range of therapeutic areas including genetic, cardiometabolic, complement-mediated diseases and central nervous system.

ADARx currently has multiple active programs in development with the lead candidate in the clinic. We are well-financed by a syndicate of highly regarded investors.

ADARx Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

Disclosure Statement

• The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position.
• Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
• The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual target bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, type and length of experience within the industry, and other job-related factors permitted by law.
• Total Compensation includes base salary; benefits: medical, vision, and dental insurance; life insurance; 401(k) matching program; paid time off; paid holidays; Employee Assistance Program; and other employee benefits. This role may also be eligible for short-term or long-term incentive compensation, including but not limited to cash bonuses.
• Following a conditional offer of employment, satisfactory completion of a background check (including criminal records check) is required prior to beginning employment. Any offer of employment may be rescinded if the background check reveals disqualifying information, and/or it is discovered that the candidate knowingly withheld or falsified information. Failure to satisfactorily complete the background check may affect the continued employment of a current NAI employee who was conditionally offered the position.