Sr. Director / Executive Director, Drug Product Development

Boston, Massachusetts, United States; Remote; San Francisco, California, United States; Seattle, Washington, United States

About Jade Biosciences

Jade Biosciences is focused on developing innovative, best-in-class therapies to address critical unmet needs in autoimmune diseases. Our lead candidate, JADE101, is designed to inhibit the cytokine APRIL (A Proliferation‑Inducing Ligand) and is being developed for the treatment of immunoglobulin A nephropathy (IgAN), a chronic kidney disease that can impair kidney function over time. JADE101 aims to reduce harmful IgA antibodies, lower proteinuria, and preserve long‑term kidney function. A Phase 1 healthy‑volunteer study is ongoing, with interim, biomarker‑rich data expected in the first half of 2026. Jade’s pipeline also includes a second development candidate, JADE201, and an undisclosed antibody discovery program, JADE‑003, both currently in pre‑clinical development. For more information, visit JadeBiosciences.com and follow us on .

Role Overview

We are seeking a strategic, highly skilled and motivated Sr. Director / Executive Director of Drug Product Development to join our dynamic team. The successful candidate will lead our efforts in the development and manufacturing of high‑concentration biologic drug products, with pre‑filled syringes and autoinjectors intended as the final product presentation. The ideal candidate will be experienced in setting strategic direction and hands‑on leadership of the development and manufacturing of biologic combination products. This position requires a deep understanding of technical and regulatory aspects of combination product development, including drug product formulation and fill / finish process, primary container development, stability, combination product design, verification, and validation, and assembly, labeling, and packaging processes.

Key Responsibilities

Combination Product Development

• Champion the development of the target combination product presentation (pre‑filled syringe / autoinjector). Collaborate with internal and external resources to achieve a combination product presentation suitable for patient use.
• Ensure rigorous design verification and validation studies are planned to meet all functional and safety criteria set by regulatory guidance from FDA, EMA and ROW.
• Manage the execution of human factors studies to evaluate the usability of combination products, focusing on enhancing user experience and safety.
• Leverage the analysis of study results to drive strategic improvements in product design and functionality.

Drug Product Manufacturing Oversight

Strategic Leadership and Vision

Late‑Stage Process Validation Leadership

Regulatory and Compliance

Qualifications

Position Location

This is a remote role; periodic travel to team and company events is required.

The anticipated salary range for candidates for this role at the Sr Director level is $255,000 – $280,000 and at the Executive Director level is $280-$310,000. The final salary offered will depend on several factors, which may include, but is not limited to, relevant years of experience, educational background, and geography.

As part of the I‑9 verification of authorization to work in the United States, Jade Bioscience participates in E‑Verify. To learn more about E‑Verify please review this poster.

Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

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