Post-Doctoral Research Fellow Functional genomics and RNA Biology

Overview

Fred Hutchinson Cancer Center is an independent nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation HIV / AIDS prevention immunotherapy and COVID-19 vaccines Fred Hutch has earned a reputation as one of the worlds leading cancer infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology infusion radiation proton therapy and related services and network affiliations with hospitals in five states. Together our fully integrated research and clinical care teams seek to discover new cures to the worlds deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration compassion determination excellence innovation integrity and respect. Our mission is directly tied to the humanity dignity and inherent value of each employee patient community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Subramaniam lab at Fred Hutchinson Cancer Center is recruiting a Postdoctoral Research Fellow to study mechanisms of mRNA translation and post-transcriptional regulation in human cells. Our group uses high-throughput experimental and computational approaches to understand how mRNA sequence elements and regulatory factors control gene expression in both physiological and disease contexts.

Current projects leverage ReLiC a high-throughput CRISPR screening platform that we recently developed to systematically discover factors that control translation and mRNA stability on a genome-wide scale (Nugent et al. Nature Methods 2025). The fellow will lead projects that build on this platform and develop new questions and tools in this space. We are particularly interested in understanding the effects of cell identity environmental stresses and subcellular mRNA localization on post-transcriptional gene regulation. We are also actively studying the role of non-canonical translation events in antiviral immunity.

The Subramaniam lab is part of the Basic Sciences Division and the Computational Biology Program at Fred Hutch providing a collaborative environment at the interface of molecular biology functional genomics and data science. Fred Hutch hosts more than 200 postdoctoral fellows and offers mentoring and career development resources through the Office of Scientific Career Development and the Student / Postdoc Advisory Committee. More information about the lab can be found at .

To apply please submit a CV and a cover letter along with contact information for 2 references. The cover letter should specifically address how your background and interests align with the above research directions.

Responsibilities

• Develop and lead an independent research project that aligns with the labs interests in mRNA translation and post-transcriptional regulation.
• Design perform and analyze deep-sequencing experiments to discover regulatory RNA elements and trans-acting factors.
• Use targeted biochemical and genetic approaches to characterize RNA sequence motifs and regulatory complexes.
• Learn and apply computational methods to analyze large-scale sequencing datasets.
• Present findings in group meetings seminars and conferences.

Opportunities and Expectations :

Qualifications

MINIMUM QUALIFICATIONS :

PREFERRED QUALIFICATIONS :

We are particularly interested in candidates who think quantitatively and rigorously about biological problems and who are motivated to develop an independent line of work within the broader themes of the lab.

To apply please submit a CV and a cover letter along with contact information for 2 references. The cover letter should specifically address how your background and interests align with the above research directions.

The annual base salary range for this position is from $77976 to $95014 and pay offered will be based on experience and qualifications.

This position may be eligible for relocation assistance.

This position is not eligible for H-1B sponsorship at this time.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health well-being and financial security. Benefits include medical / vision dental flexible spending accounts life disability retirement family life support employee assistance program onsite health clinic income-based child care subsidy tuition reimbursement paid vacation (22 days per year) paid sick leave (up to 30 calendar days per occurrence of a qualifying reason) paid holidays (13 days per year) and paid parental leave (up to 4 weeks).

Additional Information

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We do not discriminate on the basis of race color religion creed ancestry national origin sex age disability (physical or mental) marital or veteran status genetic information sexual orientation gender identity political ideology or membership in any other legally protected class. We desire priority referrals of protected veterans. If due to a disability you need assistance / and or a reasonable accommodation during the application or recruiting process please send a request to Human Resources at or by calling .

Key Skills

Bioinformatics,Genetics,R,Biochemistry,Cell Biology,Research Experience,Statistical Software,Cell Culture,Molecular Biology,Data Analysis Skills,Flow Cytometry,Microscopy

Employment Type : Full-Time

Experience : years

Vacancy : 1

Monthly Salary Salary : 77976 - 95014