Sr / Prin Scientist, Protein Production & Characterization

Job Description

Job Description

Location : Onsite | Branford, CT | Full-Time

Join a company where your science will directly shape the future of cancer immunotherapy.

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, is anticipated to enter clinical trials in Fall 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of over 47 FTEs in R&D, business development and operations with immediate plans for additional growth. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston / New York City corridor.

We're hiring a Senior or Principal Scientist to join our Biotherapeutics team collaborative group focused on designing and advancing first-in-class immune-engaging biologics. If you’re a protein scientist with expertise in protein production who thrives in the lab and wants your work to move swiftly toward patients, this role offers real opportunity, purpose, and scientific challenge.

What You’ll Work On

• Lead antibody production from idea to construct to bench — including expression, purification, and characterization
• Optimize expression and purification methodologies (affinity, IEX, SEC, etc.) for novel antibodies and multispecific formats that power our next-generation immunotherapies
• Contribute to developability assessments with platforms like SPR, BLI, DSC, DLS, ciEF, and LC-MS
• Improve key attributes like affinity, stability, specificity, and PK using modern tools and data
• Collaborate across functional teams to support candidate selection and preclinical development
• Develop and refine functional assays for biologic characterization
• Present findings in a clear, compelling way to multidisciplinary teams
• Mentor junior scientists and help shape our growing discovery organization

What You Bring

MS with 10+ years in antibody production roles

What You’ll Gain

Why You’ll Love Working Here

Additional Info

Search Keywords

Antibody Production | Bispecific Antibodies | Protein Engineering | Biotherapeutics | Biologics Development | T Cell Engager | Branford Biotech Jobs | Scientist Antibody Discovery | Immunotherapy Careers | Cancer Biotech | Molecular Biology | Biotech Scientist CT | New Haven Biotech | Oncology Drug Discovery | EvolveImmune Careers