Senior Director, Biostatistics

Overview

Senior Director, Biostatistics at Rapport Therapeutics. This role shapes the design, analysis, and interpretation of clinical trial data for precision neuromedicine programs. Reporting to the VP of Biometrics, you will collaborate with multidisciplinary teams to ensure statistical rigor and the highest standards of data integrity throughout the drug development process.

Responsibilities

• Contribute to the design of clinical trials, including writing or reviewing statistical sections of protocols and statistical analysis plans (SAPs).
• Perform and validate statistical analyses of clinical trial data using SAS and / or R in accordance with regulatory and internal standards.
• Support the generation of tables, listings, and figures (TLFs) and contribute to the interpretation of results.
• Collaborate with Clinical and Regulatory teams to provide statistical input to study reports, regulatory submissions, and publications.
• Participate in the development and review of case report forms (CRFs) and data management plans to ensure accurate data collection aligned with study objectives.
• Ensure compliance with CDISC standards (SDTM, ADaM) and regulatory guidelines (ICH, FDA, EMA).
• Assist in the development, validation, and documentation of statistical methodologies and processes.
• Oversee and manage external CROs and vendors to ensure high-quality and timely deliverables.
• Participate in cross-functional team meetings, providing statistical support and insights to influence decision-making.
• Ensure all statistical activities comply with regulatory guidelines and company policies.
• Assist in the preparation of regulatory documents, including Investigational New Drug (IND) applications and New Drug Applications (NDAs).
• Contribute to development of internal statistical processes, SOPs, and initiatives.

Qualifications

What Makes Rapport Special

Your Compensation

We expect the hiring range for this role to be $270,000 to $295,000. The actual offer will reflect factors including relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, Rapport offers a comprehensive benefits package and transparency around salary ranges for every level within the company.

Hybrid Work Environment

We prioritize in-person connection with Rapptors. Team members are onsite at our Boston office on Tuesday and Wednesday. Starting January 2026, onsite days will shift to three days per week to enhance collaboration and innovation.

Rapport Therapeutics is an equal opportunity employer and will not discriminate on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by law.

Note to Employment Agencies

Please do not forward agency resumes. The company will not be responsible for fees related to unsolicited resumes.

CCPA disclosure notice can be found here.

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