Associate Scientist 2

We're Hiring : Associate Scientist 2!

We are seeking a dedicated and experienced Associate Scientist 2 to join our dynamic research team. The ideal candidate will contribute to innovative scientific projects, conduct advanced research, and support the development of cutting-edge solutions in our laboratory environment.

Location : New Haven, CT

Work Mode :  On-site

Role : Associate Scientist 2

Position Summary :

The position is required to join the Injectable Drug Product Development group of Alexion–AstraZeneca Rare Disease Pharmaceuticals’ Pharmaceutical Development and Clinical Supply (PDCS) department. The job entails experimental work on various aspects of drug product characterization, including analytical testing, biophysical comparability testing, and process development to support drug product manufacturing. The ability to work with minimal supervision as well as part of the team is essential. The position entails execution of the studies, data processing and compiling to generate development reports as well as other required documentation.

Responsibilities :

With some supervision, design and execute development studies for pharmaceuticals’ clinical drug candidates and commercial products, characterizing protein drug conformational and colloidal stability using industry standard methodology (e.g., circular dichroism, differential scanning fluorimetry, analytical ultracentrifugation, size-exclusion chromatography with multi-angle light scattering detection, etc.)

Prioritize multiple assigned tasks and projects; work independently as well as part of the team

Execute drug development studies including physico-chemical characterization, UPLC analysis, and stability studies for Alexion-AstraZeneca rare disease pharmaceuticals’ drug candidates and commercial products

Assist in preparation of internal technical reports on the executed studies with minimal supervision

Participate in cross-functional development team

Qualifications : Required :

BS or MS degree in Biochemistry, Pharmaceutical Science, Chemical Engineering, or relevant field with 2 to 4 years relevant work experience with a pharmaceutical or biotechnology company

Solid understanding of protein stability, thermodynamics, and mechanism of protein degradation

Experience working with imaged capillary electrophoresis (iCE / Maurice), H / UPLC’s (IEX, SEC), DLS, CD, DSC, AUC, and NanoTemper is desirable

Ability to execute experiments with minimal supervision

Ability to work collaboratively and adhere to timelines

Excellent interpersonal, collaborative and communication skills

Experience with software packages like MS Office (Word, Excel, Outlook, PowerPoint)

Ability to work in a lab environment requiring lifting / carrying 15 / 30 pounds (unassisted / assisted), working with biological, infectious, and hazardous materials; gowning / degowning PPE; use of computer and communication tools

Preferred :

Experience working with sub-visible particulates characterization and testing

Experience with biophysical testing and analytical testing

Familiarity with regulatory guidelines

High proficiency in MS Office software

Experience with electronic record keeping software like ELN, EndNote, e-logbooks; maintenance of laboratory instrumentation (PMs, data backup, software upgrades)

Initiative in problem solving and scientific challenges

Strong people skills and effective communication