Senior Systems Engineer

Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment. Kidney stone disease is a common, painful condition that consumes vast amounts of healthcare resources each year. Our team is led by executives and investors with a proven track record of commercializing paradigm-shifting devices to meet unmet needs within urology.

Are you ready to change the future of kidney stone treatment? We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere.

Summary :

We are seeking a highly capable Senior Systems Engineer to drive system-level requirements, architecture, and interface definition across a complex multi-product medical device ecosystem. This role is central to shaping next-generation endoscopic platforms, capital equipment, embedded software, and multiple disposables.

You will own the creation, decomposition, and validation of requirements across hardware, software, and disposables. You will play a critical role in defining system architecture, managing interfaces between subsystems, guiding design teams, and ensuring external development partners deliver against clear, testable, and appropriately flexible requirements.

This is a deeply cross-functional that directly impacts the company's 4-year product pipeline and the future of clinically impactful technologies in the kidney stone space.

In This Role, You Will :

Requirements Development & Ownership

Own the development of system-level and subsystem-level requirements , including :

• performance requirements (fluidics, vision, disposables, embedded systems),
• interface requirements,
• regulatory compliance requirements,
• Lead decomposition of user needs into clear, measurable system and subsystem requirements
• Ensure traceability is complete across the full lifecycle of the system

System Architecture & Interface Leadership

Cross-Functional & External Collaboration

Work directly with external contract design firms by :

Risk & Systems Engineering Processes

Who You Will Report To :

Requirements :

What We Offer :

At Calyxo, you will be part of a knowledgeable, high-achieving, experienced and fun team. You will work in a diverse work environment with experienced, proven leaders and have an opportunity to shape our company culture. You will experience constant learning and dynamic challenges to help you grow and be the best version of yourself.

We also offer an attractive compensation package, which includes :

Calyxo is deeply committed to fostering an environment where diversity and inclusion are not only valued but also prioritized. We believe a diverse and inclusive community empowers us to act courageously, care deeply, and dream boldly to impact people in big ways. Diverse viewpoints bring diverse capabilities, which strengthen our focus and fuel our growth.

Calyxo is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify their identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

Disclaimer :

At Calyxo, we prioritize a transparent and structured interview process to ensure the best fit for both our candidates and our team. Please be aware of the following :

We appreciate your interest in joining Calyxo and look forward to getting to know you through our official channels.