Enterprise Architect (Staff)

21 hours ago Be among the first 25 applicants

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visitguardanthealth.comand follow the company onLinkedIn,X (Twitter)andFacebook.

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visitguardanthealth.comand follow the company onLinkedIn,X (Twitter)andFacebook.

About The Role

We are seeking a strategic and hands-on Enterprise Architect to design and evolve Guardant’s technology ecosystem as we scale 5x over the next two years. This role is enterprise-wide, with authority to establish architectural standards, guide platform development, and accelerate delivery of reusable services and components across the business.

The Enterprise Architect will partner with engineers, product, security, data science, and clinical operations teams to ensure our systems are scalable, secure, compliant, and patient-impact driven.

Key Responsibilities

Strategic Enterprise Architecture Define and govern Guardant’s enterprise architecture, aligning technology capabilities with business priorities and oncology innovation goals.

Reusable Platforms & Components Design shared platforms, modular services, and reusable components that enable faster delivery, reduce duplication, and improve scalability.

Scale & Performance Architect cloud-based systems to handle 5x growth in lab throughput, data analytics, and digital engagement within 24 months.

Data & Analytics Enablement Define enterprise data strategies and platforms for governance, interoperability, real-time analytics, and AI / ML pipelines.

Cloud Transformation Drive an cloud-first architecture (AWS), ensuring resilience, elasticity, security, and cost efficiency at scale.

Security & Privacy by Design Embed security and privacy controls into every platform, ensuring compliance with HIPAA, GDPR, CLIA, CAP, and FDA (21 CFR Part 11).

Governance & Standards Establish reference architectures, patterns, and frameworks to reduce technical debt, improve adoption, and enforce consistency across engineering teams.

Innovation & Emerging Tech Evaluate and introduce new technologies (e.g., automation, event-driven architectures, AI / ML accelerators) that strengthen Guardant’s competitive edge.

Influence & Mentorship Act as a trusted advisor to the engineering leaders, while mentoring architects and engineers across the company.

Qualifications

10+ years of progressive experience in software engineering and architecture, with 5+ years in enterprise / solution architecture leadership.

Bachelor’s degree in Computer Science, Management Information Systems, Software Engineering, Electrical Engineering, Computer Engineering, Information Systems, Bioinformatics, or a related technical field required.

Proven ability to design and scale digital and enterprise platforms in cloud (AWS) environments.

Strong expertise in modular architectures, reusable platforms, and component-driven design.

Experience with lab informatics, clinical systems, or healthcare data platforms strongly preferred.

Deep knowledge of security, compliance, and healthcare interoperability standards (e.g., HL7, FHIR, LOINC).

Familiarity with authorization policy frameworks and applying them to flexibly protect assets and resources.

Exceptional communication and leadership skills, with ability to influence executives, engineers, and clinical stakeholders.

Preferred Qualifications

Experience designing reusable platforms in diagnostics, biotech, or healthcare technology companies.

Track record of building enterprise-wide architectures that accelerated delivery while reducing integration complexity.

Success Metrics

Delivered AWS-based architectures supporting 5x scale in lab throughput, analytics, and digital services.

Established reusable platforms / components that shortened development cycles and improved efficiency.

Reduced technical debt and system fragmentation while enabling faster feature and product launches.

Implemented governance frameworks that improved security, compliance, and platform adoption across teams.

Hybrid Work Model :

This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person / onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate’s compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need. Primary Location : Palo Alto, CA Primary Location Base Pay Range : $170,700 - $234,750 Other US Location(s) Base Pay Range : $145,100 - $199,550 If the role is performed in Colorado, the pay range for this job is : $153,600 - $211,300

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk / office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our

Privacy Notice for Job Applicants

Please visit our career page at : http : / / www.guardanthealth.com / jobs /

Seniority level

Seniority level Mid-Senior level

Employment type

Employment type Full-time

Job function

Job function Information Technology

Referrals increase your chances of interviewing at Guardant Health by 2x

Menlo Park, CA $93,000 - $151,000 2 weeks ago

Mountain View, CA $177,000 - $263,000 1 week ago

Senior Cloud Architect (Director, Cloud Operations)

South San Francisco, CA $175,000 - $250,000 2 weeks ago

Principal Solutions Architect – Cloud & Engineering

Alameda, CA $128,000 - $256,000 1 week ago

Palo Alto, CA $150,000 - $200,000 14 hours ago

Santa Clara, CA $187,500 - $288,750 2 days ago

Solutions Architect - Digital Native Business

We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.

J-18808-Ljbffr