Oncology Principal Investigator

Oncologist / Principal Investigator - Clinical Research leadership

Location: Los Angeles, CA (relocation assistance provided)

Employment Type: Full-Time, On-Site

Salary: $750k+ base salary, bonuses and incentives

Overview

We are representing an exceptional research-focused oncology organization seeking a Principal Investigator (PI) to oversee a highly experienced clinical team and drive breakthrough studies with biotech sponsors.

This is a full-time, research-only role, offering the opportunity to guide cutting-edge oncology trials in a fast-growing, data-driven clinical environment.

The position is ideal for an oncologist who wants to transition from purely clinical practice into a leadership role at the intersection of science, medicine, and industry, helping advance next-generation cancer therapies.

Key Responsibilities

• Serve as the Principal Investigator for oncology trials across multiple modalities and sponsors.
• Provide medical oversight, ensure patient safety, and maintain protocol compliance and data integrity.
• Supervise and mentor sub-investigators, nurse practitioners, and clinical operations staff.
• Collaborate closely with sponsors, CROs, and internal study teams to drive enrollment and site performance.
• Support scientific and operational strategy, SOP refinement, and future site development.
• Participate in investigator meetings, safety reviews, and regulatory inspections.

Ideal Candidate

• MD or DO with board certification or eligibility in Hematology/Oncology (or related discipline).
• Licensed or license-eligible to practice medicine in California.
• 1–5+ years post-fellowship experience (early-career attendings encouraged to apply).
• Demonstrated clinical excellence and the ability to manage oncology patients in a research setting.
• Prior Sub-I or PI experience preferred but not required — full GCP training and mentorship provided.
• Strong communication skills, collaborative mindset, and enthusiasm for research and innovation.
• Must be committed to a full-time, on-site position.

Why This Opportunity

• Exceptional Organization — culture of scientific rigor, integrity, and collaboration.
• Exposure to Cutting-Edge Oncology Programs — work on next-generation therapeutic approaches.
• Leadership Trajectory — opportunity to expand into multi-site or network-level leadership.
• Competitive Compensation — highly attractive package with relocation and performance incentives.

This search is being managed exclusively by Plexus Partners.

Interested candidates can submit a CV or express interest in confidence to:

elliot@plexus-partners.com