Talent.com
Principal Investigator
Principal InvestigatorMetric • Quincy, MA, US
Principal Investigator

Principal Investigator

Metric • Quincy, MA, US
[job_card.variable_days_ago]
[job_preview.job_type]
  • [job_card.full_time]
[job_card.job_description]

Job Description

Opportunity : Principal Investigator (General Medicine)

Metric Bio is partnering with a high-performing and rapidly expanding clinical site network based in Massachusetts, in the search for an accomplished Principal Investigator specialising in General Medicine . This is a unique opportunity to lead meaningful clinical research, drive innovation, and directly impact patient outcomes within a cutting-edge US-based organisation.

The Role :

As the Principal Investigator, you will provide expert medical leadership across multiple clinical trials, ensuring scientific integrity, regulatory compliance, and the highest standards of patient safety. You’ll be a key contributor in shaping research strategy, guiding clinical teams, and building strong collaborations with sponsors and stakeholders.

Key Responsibilities

  • Serve as the lead Principal Investigator across general medicine clinical trials
  • Oversee all aspects of study conduct, ensuring alignment with protocol, GCP, and FDA standards
  • Conduct medical evaluations, determine eligibility, and monitor patient safety
  • Provide expert input into feasibility assessments and study design
  • Safeguard data quality and ethical integrity across trials
  • Develop and maintain strong sponsor and regulator relationships
  • Mentor and support Sub-Investigators and research teams
  • Champion clinical excellence and continuous process improvement

Required Qualifications & Experience

  • MD / DO with active and unrestricted US medical license.
  • Minimum 5 years’ post-licensure experience in general or internal medicine
  • Direct involvement in 10 or more clinical trials (Phase II–IV preferred) as Principal Investigator or Sub-Investigator.
  • Deep understanding of GCP, FDA regulations, ICH guidelines, and clinical governance
  • Proven track record in clinical leadership and decision-making
  • Excellent communication, patient-centric approach, and collaborative mindset

    • What’s on Offer

  • Competitive compensation package + comprehensive benefits
  • Opportunity to lead high-impact trials across varied therapeutic areas
  • Innovative, collaborative research environment
  • Professional development & leadership support
  • Make a significant contribution to improving future patient care

    • Interested in Applying?

    If you are an experienced physician with a passion for research leadership and meet the clinical trial experience requirement, we would love to hear from you.

    Contact Metric Bio : oli.oldham@metric-search.com

    [job_alerts.create_a_job]

    Principal Investigator • Quincy, MA, US

    [internal_linking.similar_jobs]
    Principal Specialist Engineering Services

    Principal Specialist Engineering Services

    Raytheon • Reading, MA, United States
    [job_card.full_time]
    MA135 : Innovation Dr Tewks Bdg 300 836 North Street Building 300, Tewksbury, MA, 01876 USA.Person, or Immigration Status Requirements : . The ability to obtain and maintain a U.As a Principal Speciali...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Principal Developer

    Principal Developer

    Boston Red Sox and Fenway Sports Management • Boston, MA, US
    [job_card.full_time]
    Members of the Baseball Systems team at the Boston Red Sox are focused on designing, building, and refining the software and data pipelines used within Baseball Operations.These tools and applicati...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Principal Success Architect

    Principal Success Architect

    Meltwater • Boston, MA, United States
    [job_card.full_time]
    We are hiring a Principal Success Architect to lead strategic client value realization for our top enterprise customers across North America and Global. You will act as the senior-most post-sales ad...[show_more]
    [last_updated.last_updated_variable_hours] • [promoted] • [new]
    Investigator

    Investigator

    Ethos Risk Services • Boston, MA, USA
    [job_card.full_time]
    [filters_job_card.quick_apply]
    Ethos Risk Services is a leading insurance claims investigation and medical management company, specializing in surveillance and fraud detection. At the forefront, we provide accurate data and actio...[show_more]
    [last_updated.last_updated_30]
    OBGYN Director | Near Portland, OR | $100,000 Sign-On

    OBGYN Director | Near Portland, OR | $100,000 Sign-On

    Jackson Physician Search • Salem, US
    [job_card.full_time]
    A large community hospital 45 minutes from Portland, OR is searching for a physician leader to oversee Women's Services.The typical schedule consists of 3 days in clinic, 1 OR day, and 1 dedicated ...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Clinician (2nd year Masters)

    Clinician (2nd year Masters)

    Spectrum Health Systems, Inc • Haverhill, MA, United States
    [job_card.part_time]
    Haverhill, MA - Haverhill Outpatient Program.Health, dental, vision insurance (30+ hours only).Tuition reimbursement (20+ hours only). Discounts on wide array of services / entertainment.Providing doc...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Master's Clinician

    Master's Clinician

    BAMSI • Whitman, MA, United States
    [job_card.full_time]
    Multiple Clinician Opportunities Available.We are hiring for several clinician positions with flexible schedules.Hours vary from full-time to fee-for-service arrangements.Join our team and choose t...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Paid Research Study Contributor (Earn Up to $3,000 / Study) (Hiring Immediately)

    Paid Research Study Contributor (Earn Up to $3,000 / Study) (Hiring Immediately)

    Maxion Research • Danvers, Massachusetts, US
    [job_card.part_time]
    Join Our Part-Time Research Studies Today!.Are you eager to earn extra income from the comfort of your home? We are looking for motivated individuals to participate in paid research studies includi...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Principal Scientist

    Principal Scientist

    Galois, Inc. • Boston, MA, United States
    [job_card.full_time]
    From building digital engineering tools that make space exploration safer to verifying cryptographic libraries that protect some of the world’s most valuable data, Galois develops technology to gua...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Pulmonary Physician, South Weymouth, MA

    Pulmonary Physician, South Weymouth, MA

    HealthEcareers - Client • South Weymouth, MA, USA
    [job_card.full_time] +1
    Mass General Brigham is seeking a.Board Certified or Board Eligible, Pulmonary Physician.Boston with a primary clinic location in South Weymouth, MA. This is not an academic / teaching opportunity, b...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Assistant Professor- Cybersecurity Focus, Department of Criminal Justice

    Assistant Professor- Cybersecurity Focus, Department of Criminal Justice

    InsideHigherEd • Bridgewater, Massachusetts, United States
    [job_card.full_time]
    Assistant Professor- Cybersecurity Focus, Department of Criminal Justice.Bridgewater State University’s Department of Criminal Justice invites applications for a full-time, tenure-track position to...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Acquired Brain Injury - Moving Forward Plan Waiver Director

    Acquired Brain Injury - Moving Forward Plan Waiver Director

    State of Massachusetts • Danvers, MA, United States
    [job_card.full_time] +1
    This position is located in the Northeast Regional Office in Danvers, Ma.The Department of Developmental Services (DDS) was invited by Executive Office of Health and Human Services (EHS) to develop...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Academic / Faculty / Research Physician

    Academic / Faculty / Research Physician

    Amergis Locum Tenens • Raynham, Massachusetts, United States
    [job_card.permanent]
    Our client in Raynham, MA is seeking coverage for clinical trials in June and August.If you're interested and would like to be considered please inquire with an updated CV.We look forward to speaki...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Principal Engineer

    Principal Engineer

    Constellation Energy • Accord, MA, US
    [job_card.full_time]
    As the nation's largest producer of clean, carbon-free energy, Constellation is focused on our purpose : accelerating the transition to a carbon-free future. We have been the leader in clean ener...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Principal Machine Learning Engineer

    Principal Machine Learning Engineer

    Simplisafe • Boston, Massachusetts, United States
    [job_card.full_time]
    SimpliSafe is a leading innovator in the home security industry, dedicated to making every home a safe home.With a mission to provide accessible and comprehensive security solutions, we design and ...[show_more]
    [last_updated.last_updated_30] • [promoted]
    Senior Property Claims Investigator (BOSTON)

    Senior Property Claims Investigator (BOSTON)

    Usaa • Boston, MA, United States
    [job_card.full_time]
    Remember to check your CV before applying Also, ensure you read through all the requirements related to this role.At USAA, our mission is to empower our members to achieve financial security throug...[show_more]
    [last_updated.last_updated_1_day] • [promoted]
    Principal

    Principal

    Lexer Group • Boston, MA, US
    [job_card.full_time]
    Principal Engineering Leader - Boston Area.Lead mechanical, electrical, plumbing, and fire protection engineering for a wide range of complex building projects. Provide technical mentorship and lead...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]
    Remote Private Detectives and Investigators - AI Trainer ($80-$120 per hour)

    Remote Private Detectives and Investigators - AI Trainer ($80-$120 per hour)

    Mercor • Brockton, Massachusetts, US
    [filters.remote]
    [job_card.full_time]
    About the Role • • Mercor is seeking experienced • •Private Detectives and Investigators • • to support a leading AI lab in advancing research and infrastructure for next-generation machine learning sys...[show_more]
    [last_updated.last_updated_variable_days] • [promoted]