Summer Intern, Computational Biology & Bioinformatics

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Summer Intern, Computational Biology & Bioinformatics will support Translational Genetics research at Arrowhead Pharmaceuticals by contributing to the development and improvement of computational biology and bioinformatics workflows. This internship offers hands-on experience working with next-generation sequencing data, analytical pipelines, and AI-enabled tools in a collaborative research environment. The intern will help connect diverse datasets and improve how biological data is processed, documented, and interpreted to support scientific decision-making.

This is an 11-week Summer Internship Program paying $27.00 per hour and requires full-time, on-site work five days per week at the designated location.

Responsibilities

• Support development and enhancement of computational biology and bioinformatics workflows.
• Assist with analysis and integration of sequencing and multi-omics datasets.
• Contribute to automation, quality control, and data organization efforts within analytical pipelines.
• Help ensure accurate capture, validation, and use of experimental metadata across systems.
• Create summaries, visualizations, or reports to support data interpretation and project updates.
• Collaborate with computational and experimental scientists to align workflows with research needs.
• Present progress updates and findings to the project team and participate in technical discussions.
• Support documentation efforts to improve reproducibility and consistency of analyses.

Requirements

• Currently pursuing a PhD program in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field.
• Proficiency in Python and/or R for statistical genetics and data analysis workflows.
• Familiarity with NGS or RNA-seq data analysis concepts.
• Understanding of experimental metadata structures and data organization principles
• Excellent verbal and written communication skills and ability to collaborate in a cross-functional research environment.

Preferred

• Experience with bioinformatics workflows or pipeline development.
• Familiarity with workflow management tools, visualization platforms, or cloud-based analysis environments.
• Exposure to LLM-based or AI-assisted tools for data analysis or automation.
• Experience working with bulk or single-cell sequencing datasets.
• Interest in building scalable, reproducible computational workflows to support biomedical research.

California pay range $11,440—$11,440 USD

Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.