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Tenvie Therapeutics
Director/Senior Director, DMPKTenvie Therapeutics • Brisbane, CA, US
Director/Senior Director, DMPK

Director/Senior Director, DMPK

Tenvie Therapeutics • Brisbane, CA, US
21 days ago
Salary
$240,000.00 yearly
Job type
  • Full-time
  • Quick Apply
Job description

Director/Senior Director, DMPK Tenvie is a biotechnology company committed to engineering small molecules that transform the treatment of neurological diseases.

The company’s foundation is purpose-built with a diverse portfolio of small molecules and a proven team of CNS drug developers to rapidly deliver multiple clinical assets.

Tenvie is advancing a pipeline of therapeutics focused on treating neurological, cardiometabolic, and ophthalmic diseases.

Its portfolio of wholly owned, highly brain-penetrant, and precision-designed peripherally restricted small molecules address three key drivers of disease:

  • resolving inflammation, rescuing metabolic dysfunction, and restoring lysosomal function.
  • The company’s most advanced programs target NLRP3 and SARM1, with additional programs in preclinical development.
  • We are looking for a highly motivated and skilled DMPK Scientist with scientific leadership experience in small molecule drug discovery and early development.
  • Reporting to the Vice President, DMPK & Clinical Pharmacology, this role will direct the translational ADME and PK/PD strategies for drug discovery and early development of small molecule therapeutics.
  • This leader will drive pipeline progression from lead identification and optimization through IND with key deliverables of human PK and efficacious dose predictions and clinical risk assessment based on translating in vitro and nonclinical data. This is an excellent opportunity to join a biotech company with groundbreaking work in the field. This role is onsite.

JOB RESPONSIBILITIES:

  • Be a subject matter expert in DMPK who applies a robust and scientifically rigorous DMPK strategy across the pipeline of small molecule drug discovery to early development Guide interdisciplinary project teams to integrate DMPK strategies of ADME and PK/PD principles early in discovery Partner with chemistry, biology, pharmacology, toxicology, biomarker, and clinical to drive progression of lead molecules to IND- and clinical-readiness Manage and oversee external vendors for completing in vitro and in vivo ADME, PK and TK studies Utilize PK and PK/PD modeling for human dose and PK predictions and drug interaction risk assessments Serve as a subject matter expert to author and review Nonclinical Pharmacology sections of regulatory (IND/CTA) filings, IB updates, and responses to regulatory queries QUALIFICATIONS: MS or PhD in Drug Metabolism, Pharmacokinetics, Chemistry, or related scientific discipline with a minimum 8+ years of pharmaceutical drug discovery and development experience Strong track record of supporting drug discovery and development through executing and updating ADME, PK, and translational strategy Excellent critical thinking and scientific skills with proven scientific expertise in small molecule metabolism and pharmacokinetics Demonstrated success working effectively and collaboratively on cross-functional projects teams Expected salary range: $240,000-290,000 annual base salary Tenvie is proud to be an Equal Opportunity Employer.
  • Our goal is to have a diverse workforce.
  • We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law.
  • All employment is decided on the basis of qualifications, merit and business need. Powered by JazzHR
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Director/Senior Director, DMPK • Brisbane, CA, US

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