Proteomics Principal Investigator

Kelly® Science & Clinical is currently seeking a Proteomics Principal Investigator for a direct hire opportunity for one of our clients, a multi-omics biotechnology company in San Diego, CA. If you are driven by the prospect of translating cutting-edge scientific discoveries into tangible advancements and are poised to advance your career, join us as we pioneer progress in the biotechnology industry.
Workplace: Onsite in San Diego, CA
Position: Proteomics Principal Investigator
Salary: $135,000-185,000
Overview
Join one of San Diego's most innovative biotechnology environments, where science and technology are advancing the frontiers of multi-omics for precision medicine. As a leader in contract research, our client’s organization empowers clients to accelerate drug discovery and development through groundbreaking integration of high-resolution mass spectrometry, computational biology, and complex human health datasets. Their cross-disciplinary team of experts is driven by a shared passion for improving health outcomes and shaping the future of therapies with rigorous, forward-thinking science.
The Opportunity
We are seeking an accomplished and visionary Principal Investigator in Proteomics to lead multifaceted client programs and make a lasting impact on therapeutic advancement. You will drive the scientific direction of complex proteomic studies, foster innovation, and build trusted client relationships in a highly regulated CRO setting. Collaborating with exceptional minds in mass spectrometry-based proteomics and bioinformatics, you will transform raw data into actionable insights that fuel progress across therapeutic areas.
This client-facing role demands excellence in technical leadership, a flair for mentoring, and a talent for synthesizing multi-omics data into real-world solutions. You’ll thrive in our collaborative environment and set new standards for scientific achievement and client satisfaction.
Responsibilities

• Spearhead large-scale proteomics projects from conception to completion across discovery and translational research.
• Project manage client programs, ensuring timely delivery of high-quality scientific solutions while troubleshooting complex challenges in both wet- and dry-lab workflows.
• Design robust research strategies, study plans, and final reports to exceed client objectives.
• Integrate mass spectrometry data (LC-MS/MS, Orbitrap, Q-TOF, timsTOF) and advanced analysis pipelines (DDA/DIA, PRM/MRM/SRM, TMT/iTRAQ, PTM) to drive breakthrough results.
• Uphold rigorous regulatory and quality standards to deliver reliable and impactful data packages.
• Lead and mentor high-performing cross-functional teams that include biologists, chemists, clinicians, and data scientists.
• Remain on the cutting edge of scientific literature, emerging technology, and best practices in precision medicine.

Qualifications

• PhD/MD in biochemistry, biology, chemistry, pharmacology, clinical science, or related discipline (or equivalent professional track).
  • BS + 10 years’ relevant experience, MS + 5 years’ relevant experience.
• At least 5 years of proven leadership in CRO, biotech, or pharmaceutical settings, including scientific project and team management.
• Deep expertise in proteomics, mass spectrometry technologies, and associated data analysis.
• Demonstrated ability to design and execute advanced proteomics experiments, from discovery to targeted workflows and PTM analysis.
• Experience presenting complex scientific findings to clients and collaborating across departmental boundaries.
• Excellent organizational skills for managing 15+ client programs concurrently.
• Analytical mindset with an ability to interpret and communicate multidimensional scientific data.
• Passion for mentoring, training, and engaging key stakeholders internally and externally.
• Commitment to scientific rigor, accuracy, and up-to-date knowledge in precision medicine.

Why You’ll Love Working Here

• Collaborate and grow alongside leading scientists, engineers, and clinicians in San Diego’s thriving biotech community.
• Make a tangible difference by advancing treatments that enhance patient outcomes across diverse therapeutic modalities.
• Engage in a dynamic, intellectually stimulating environment with opportunities for continuous learning and innovation.

Join Us
If your qualifications align with the requirements of this role, we invite you to apply and take the next step in your career journey. Rest assured, even if this opportunity isn't the perfect match, your profile will remain within our network, ensuring you're connected to a wealth of future opportunities in the field of science and clinical research.











Join Us:
If your qualifications align with the requirements of this role, we invite you to apply and take the next step in your career journey. Rest assured, even if this opportunity isn't the perfect match, your profile will remain within our network, ensuring you're connected to a wealth of future opportunities in the field of science and clinical research.
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Why Kelly® Science & Clinical?

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About Kelly

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