Senior Manager, Portfolio Management & Operations

Senior Manager, Portfolio Management & Operations

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines is seeking a motivated individual with experience in CMC, project and portfolio management, and/or life sciences management consulting to play a critical role within the Portfolio Management group of the Pharmaceutical Development and Manufacturing (PDM) organization. This position will serve as a key business partner supporting portfolio analytics, governance operations, resource and cost management, and strategic cross-functional initiatives. The role will partner closely with cross-functional stakeholders to drive execution of critical business processes, support decision-making, and improve organizational effectiveness across a growing portfolio of discovery, development, and commercial programs.

Responsibilities:

• Partner with PDM leadership and cross-functional stakeholders to support portfolio planning, business operations, and strategic decision-making across the organization.
• Develop analyses, insights, and recommendations that enable effective prioritization, resource allocation, risk management, and execution of business objectives.
• Drive cross-functional planning and governance activities by facilitating stakeholder alignment, supporting decision-making forums, and ensuring effective follow-through on key actions and commitments.
• Develop and maintain portfolio reporting, metrics, dashboards, and other decision-support tools to provide visibility into portfolio performance, organizational capacity, risks, and opportunities.
• Support budgeting and long-range planning activities through data analysis, scenario modeling, and business insight generation.
• Lead or contribute to strategic initiatives and operational excellence efforts aimed at improving business processes, organizational effectiveness, and scalability.
• Apply structured problem-solving and analytical approaches to address complex cross-functional challenges and support informed decision-making.
• Build strong partnerships across PDM and adjacent functions to promote transparency, alignment, and effective execution of key priorities.
• Prepare and deliver clear, concise, and compelling communications, presentations, and recommendations for audiences ranging from working teams to senior leadership.

Required Skills, Experience and Education:

• B.Sc. in a scientific, engineering, business, or related discipline, with 5+ years of experience within a CMC, Project and Portfolio Management, and/or life sciences management consulting organization.
• Robust analytical and problem-solving skills with experience in scenario planning, forecasting, resource modeling, and business analytics; demonstrated ability to translate analytical insights into executive-level communications.
• Strong scientific and business acumen with the ability to connect data, portfolio priorities, resource constraints, and organizational objectives into actionable recommendations.
• Demonstrated intellectual curiosity and learning agility, with a willingness to quickly develop expertise in new business processes, functional areas, and technical domains.
• Ability to influence without authority and build productive working relationships across functions and organizational levels.
• Exceptional communication and storytelling skills with the ability to synthesize complex information into clear, concise, and compelling recommendations for senior leadership.
• Demonstrated ability to balance strategic thinking with operational execution and deliver results across complex cross-functional initiatives.
• Demonstrated success operating in fast-paced, dynamic environments with evolving priorities and ambiguity.
• Proven track record of taking ownership, identifying opportunities for improvement, and proactively driving solutions with minimal direction.
• Strong project management and facilitation skills with the ability to drive alignment, manage competing priorities, and execute effectively in ambiguous environments.

Preferred Skill:

• Advanced degree in a scientific, engineering, business, or related discipline.
• PMP or similar project management certification.

Base Pay Salary Range

$164,000 - $205,000 USD